Genetic background influences loss of heterozygosity patterns in radiation-induced mouse thymic lymphoma

Michael Hang, Yurong Huang, Antoine M. Snijders, Jian-Hua Mao

Life Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, CA 94720, USA. Undergraduate Program at Department of Molecular Cell Biology, University of California Berkeley, Berkeley, CA 94720, USA


1-5-e96-2015

Previous studies have revealed that p53 heterozygous (p53+/-) mice are extremely susceptible to radiation-induced tumorigenesis. To investigate whether genetic background influences radiation induced tumor susceptibility, we crossed p53+/- 129/Sv mice with genetically diverse strains to generate p53+/- F1 hybrids. The results showed that genetic background had a profound impact on tumor latency after exposure to gamma radiation, although the tumor spectrum did not change. We further characterized the thymic lymphomas that arose in the p53+/- mice by genome-wide loss of heterozygosity (LOH) analyses and found that genetic background strongly influenced the frequency of LOH and the loss of which parental allele on different chromosomes. Further research is needed to identify which genetic variations control the LOH patterns in radiation-induced thymic lymphomas and to investigate its relevance to human cancers. Journal of Nature and Science, 1(5):e96, 2015




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