Isomer specificity of conjugated linoleic acid on suppression of osteosarcomas

Janice Wong, Yoo Kim, Yooheon Park, Seong-Ho Lee, Seung J. Baek, Yeonhwa Park

Department of Food Science, University of Massachusetts, Amherst, USA. Department of Food and Nutrition, Korea University, Seoul, Republic of Korea. Department of Nutrition and Food Science, University of Maryland, College Park, MD 20742, USA, and Department of Biomedical and Diagnostic Sciences, University of Tennessee, Knoxville, TN 37996, USA


Osteosarcoma is an aggressive type of cancer primarily found in children and adolescents and current understanding of its etiology and treatments are rather limited. As a potential anti-cancer component, conjugated linoleic acid (CLA) has drawn significant attention in the last few decades. However, there is limited knowledge on CLA’s effect on osteosarcoma. In this report, we tested effects of two major CLA isomers on growth of a canine osteosarcoma cell line. The results in this report suggest that the trans-10,cis-12 CLA isomer, but not the cis-9,trans-11 isomer, effectively inhibits canine osteosarcoma cell growth and induces apoptosis. Treatment with trans-10,cis-12 CLA increased expression of NSAID activated gene-1 (NAG-1), suggesting that NAG-1 may mediate trans-10,cis-12 CLA-induced apoptosis, via phosphoinositol-3-kinase (PI3K) dependent mechanism. The significance of this study is that CLA might be used as a dietary supplement in prevention and/or treatment of osteosarcoma. Journal of Nature and Science, 1(4):e67, 2015



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