Association of ABO blood type with ovarian reserve

Nigel Pereira Pereira, Rony T. Elias, Brian A. Levine, Jovana P. Lekovich, Zev Rosenwaks, Steven D. Spandorfer

Weill Cornell Medical Center, New York, NY, USA


To investigate the relationship between ABO blood type and serum antimüllerian hormone (AMH) as a marker of ovarian reserve. Retrospective chart review of all potential in vitro fertilization (IVF) patients between 2010 and 2013. The percentage of patients belonging to each ABO blood type with an AMH < 1 ng/ml, < 0.5 ng/ml and < 0.16 ng/ml was calculated. Within each AMH group, means and standard deviations for age and body mass index (BMI) were also calculated. Chi-square and Student’s t tests were used to compare percentages and means between AMH groups. Complete data was available for 2394 patients. The overall distribution of ABO blood types was: 37% (A), 18.1% (B), 5% (AB), and 39.9% (O). Of the 2394 patients, 2146 (89.6%) patients were Rhesus factor positive, while 248 (10.4%) patients were Rhesus factor negative. There was no difference in the percentage of patients belonging to each ABO blood type, or mean age and BMI in the AMH < 1 ng/ml group. The AMH < 0.5 ng/ml and < 0.16 ng/ml groups had a higher percentage of older patients, but there was no difference in mean BMI. No association between blood type and AMH < 0.5 ng/ml or < 0.16 ng/ml was found, even after controlling for age. Contrary to initial investigations, our study reveals no relationship between ABO blood type and ovarian reserve. The predictive value of ABO blood type for the evaluation of ovarian reserve remains questionable. Journal of Nature and Science, 1(2):e40, 2015.

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