Click Chemistry Takes a Snapshot of DNA-RNA Hybrid G-Quadruplex in Living Cells

Takumi Ishizuka, Yan Xu

Division of Chemistry, Department of Medical Sciences, Faculty of Medicine, University of Miyazaki, 5200 Kihara, Kiyotake, Miyazaki, 889-1692, Japan


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In this study, using the click chemistry, we designed and synthesized a “click-light-up” probe to investigate whether DNA–RNA G-quadruplexs exist in living cells. Employing the reporter probe, we found that human telomere DNA and RNA form the hybrid G-quadruplex structure in living cells, providing the in cell evidence for the presence of the DNA-RNA hybrid G-quadruplex. Journal of Nature and Science (JNSCI), 2(10):e237, 2016




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