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Medical Sciences

Human Tissue Attracting Iron Particles as Proposed Mechanism Explaining the Iron and Atherosclerosis Hypothesis


Author: Abraham A. Embi

Manuscript ID: JNSCI#17-1005

Abstract:

IMPORTANCE

Atherosclerosis is a disease directly linked to high mortality and morbidity. In spite of several behavioral modification and drug therapy, the prevalence of the disease continues. Historically, it has been attributed to numerous factors; one of them is the presence of elevated serum iron levels. It has been hypothesized that iron is an essential player in the oxidation of low-level lipoproteins, radical formation and inflammation contributing to arterial plaques buildup. This manuscript introduces a Biophysical explanation as mechanism of iron attraction by human tissue

OBSERVATIONS

Published papers have documented improved survival attributed to life style modifications and drug therapy whose effects on the plaques are not yet fully understood. The human hair follicle has been described as a mini-organ possessing intrinsic metabolic processes; and when plucked are also known to maintain functions such as cellular divisions. One month ago, this author became aware the “Iron-atherosclerosis Hypothesis”; and thought of a possible correlation between published research (by this author and others) where ex vivo, and in vivo sub-dermal human hair follicles electromagnetism was externally detected. In both cases the findings were duplicated attracting iron particles through glass barriers.

CONCLUSIONS AND RELEVANCE

A novel technique introduced in 2015, has enabled via optical microscopy the documentation of magnetic fields found in living plants and animal tissue. The human hair follicle was found to exhibit biomagnetism by interacting with fine iron particles (2000 nm in diameter). It can then be inferred that as result of the blood flow dynamics and its intrinsic electron transport, electromagnetic fields are generated which could possibly interact with the arterial tissue. The relevance of this finding could be applied to explain a mechanism for the iron attraction towards the arterial walls in the “Iron-Atherosclerosis Hypothesis”.

 

Genetics

Histone acetyltransferase KAT8 and oocyte development


Author: Shi Yin, Xiaohua Jiang, Xian-Rong Xiong, Jian Li, Tej K. Pandita, Qinghua Shi

Manuscript ID: JNSCI#17-1009

Abstract:

Oocyte development is necessary for female fertility and is characterized by dramatic changes in gene expression and chromatin structure. Histone acetylation is an important epigenetic mechanism for gene regulation as it changes the chromatin structure and affects the binding ability of transcription factors to DNAs. Histone acetylation level is regulated antagonistically by two classes of enzyme, histone acetyltransferases (HATs) and histone deacetylases (HDACs). In this review, we briefly summarize the current knowledge about an important HAT, K (Lysine) Acetyltransferase 8 (KAT8), and introduce the role of this enzyme in oocyte and follicle development, which gives new insight about epigenetic and female reproduction.

 

Medical Sciences

Variability in Quantitative DCE-MRI: Sources and Solutions


Author: Harrison Kim

Manuscript ID: JNSCI#17-1002

Abstract:

DCE-MRI has been extensively used for diagnosis, prognosis and therapy monitoring of various diseases including cancer. However, it has been reported that the perfusion parameters measured by DCE-MRI largely vary across different research sites, preventing data comparison in multi-institutional clinical trials. Recently, novel perfusion phantoms have been developed to correct scanner-driven errors, enabling quality assurance of quantitative DCE-MRI measurement. However, the sources for the variability in quantitating perfusion parameters are not only MRI scanners but also software packages and imaging protocols set by the operators. In this manuscript, the various sources influencing the variability in quantitative DCE-MRI measurement are reviewed, and the proper solutions to minimize those are discussed.

 

Medical Sciences

Salvage of hemodialysis catheter in Staphylococccal bacteremia, case series and revisiting the literature


Author: Wasim S. El Nekidy, Derrick Soong, Albert Kadri, Amina Ibrahim, Islam M. Ghazi

Manuscript ID: JNSCI#17-0919

Abstract:

Central venous catheters are widely used to administer medications, provide parenteral nutrition, perform hemodynamic monitoring and carry out hemodialysis (HD). Catheter related blood stream infections are a major complication in hemodialysis patients, leading to increased mortality, morbidity and cost of treatment. Prompt treatment is essential which includes administration of appropriate systemic antibiotics and frequently, catheter removal and replacement. However, in hemodialysis patients, repeated catheter insertions may cause central vein stenosis and thrombosis which limits the future availability of hemodialysis access. Thus, minimizing vascular trauma in this patient population is of paramount concern. Lock solutions containing antibiotics and anticoagulants, instilled directly into the catheter lumen, have been successfully utilized for catheter salvage but higher rates of recurrence and complications were observed in infections resulting from staphylococcal species.

We report several cases of catheter salvage using antibiotic lock solution in staphylococcal bacteremia with the purpose of stimulating the interest in randomized clinical trials evaluating risk and benefits of catheter salvage in this patient subset in light of optimized systemic antibiotic dosing, improved lock solution use and multidisciplinary involvement, balanced with the critical need to prevent unnecessary vascular trauma.

 
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