miR-145: Revival of a Dragon in Pancreatic Cancer

Saini Setua, Sheema Khan, Kyle Doxtater, Murali M. Yallapu, Meena Jaggi, Subhash C. Chauhan

Department of Pharmaceutical Sciences and Center for Cancer Research, University of Tennessee Health Science Center, Memphis, Tennessee, USA


Emergence of the role of MicroRNA-145 (miR-145) as a tumor suppressor in pancreatic cancer, offers its potential for novel therapeutic interventions. Our recently published studies demonstrate clinical significance of miR-145 in pancreatic cancer and suggest that the dysregulation of miR-145 in human pancreatic tumors draws in parallel with the aberrant expression of an oncogenic mucin, MUC13. These studies also present a novel therapeutic strategy of restoring the downregulated levels of miR-145 in pancreatic cancer via nanoparticle mediated efficient delivery system. Journal of Nature and Science (JNSCI), 3(3):e332, 2017



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